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| Statement |
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| Although 2024 organic revenue growth is forecasted to be below our long-term targets, we remain confident in our Investor Day targets of averaging 6% to 8% organic revenue growth through 2026 and delivering meaningful margin expansion, which is supported by the sustained long-term fundamentals for drug development and our position as an industry leader |
| As we mentioned at Investor Day in September, we expect the manufacturing segment will drive the improvement towards the company’s margin expansion targets over the next 3 years, and the CDMO business is a key component of that goal |
| I mean the fact that we have a 12-month backlog, I think, is a positive |
| The demand should improve nicely |
| I mean we are quite confident that we are going to see a sequential improvement in top of the bottom line throughout the year |
| I think suffice to say, at the top end of the guidance, as we pointed out, we expect the main trends to marginally improve through the year |
| So we feel very optimistic, particularly optimistic about the CDMO business, in particular, but I’m quite optimistic about the home Manufacturing segment in terms of its importance to our client base in terms of the commonality of a lot of the work and in terms of the potential for better financial performance |
| It will definitely benefit the operating margin of that segment |
| That business, as we said in the prepared remarks, proposal levels were up in the fourth quarter, which is a good sign that work comes back very, very quickly typically |
| That business, while it won’t end fiscal 2024, where it should have been given our valuation models will have significantly better margins and significantly higher revenue not growing quite - we don’t have - our operating plan doesn’t have it growing quite at the rate that we thought it would when we bought them |
| And I think we have done a really good job as evidenced by the fact that we have had multiple regulatory audits culminating in with Vertex’s new sickle cell drug, which we are going to be producing a large amount of that |
| So we should be able to pick up meaningful share as the clients are more comfortable and less cautious and less conservative with the spending patterns, which we think will be a sequential movement through the back half of the year |
| On the share gain question, I do think we have enormous opportunities to take share in virtually everything we do, certainly in biologics, certainly in the CDMO business certainly in discovery, either and - where we have the principal amount of share |
| This includes enhanced commercial efforts through optimizing on Salesforce to accelerate revenue growth by adjusting go-to-market strategies, focusing on selling across our entire portfolio and leveraging technology to enhance sales insights, and identify earlier selling opportunities |
| So pleased with our sell-through, particularly in pharma and as the capital markets strengthen, which they will |
| We also have a culture [Technical difficulty (07:26) to (07:30)] continuous improvement at Charles River that enables us to drive operational efficiencies and cost saving actions to proactively manage our cost structure and to become an even more compelling partner for our clients for the longer term |
| Overall, our successful execution in these areas will enable us to capitalize on new business opportunities as they emerge while delivering operating margin improvement in 2024 and beyond |
| So I mean, obviously, pharma is extremely well financed |
| So our pharma business in 2023 was particularly strong |
| The top-line performance was driven by another solid year in our safety assessment business, as well as healthy growth in the RMS segment |
| So we have good line of sight on that margin accelerating throughout the year and confidence that we will be able to achieve that |
| I also talked about the seasonal ramp of our business, which Jim just alluded to, with those normal seasonal trends, we will see the margin improving throughout the year |
| The range represents earnings per share growth for approximately two to 7% with earnings growth expected to exceed revenue growth due primarily to operating margin expansion of at least 50 basis points this year |
| For the year, DSA revenue increased 7.9% on an organic basis, which met our segment outlook due to another solid year in the safety assessment business |
| As anticipated, the backlog coverage enabled us to achieve our DSA financial outlook of high single digit organic revenue growth in 2023 |
| We were very pleased to see the cancellation rates, which have gotten higher than historically - they have been historically starting to come down, and we said that that is fabulous |
| We expect demand KPIs to improve modestly once the cancellation rate subsides, which is one of the assumptions behind our DSA outlook |
| We also have very easy comps |
| We expect study volume to improve thereafter, but the first half growth rate will be lower before the easier year-over-year growth comparison and improving demand KPIs benefit the second half DSA growth rate |
| One of the reasons that we are able to navigate a volatile NHP pricing environment is our longstanding high quality NHP supply relationships, which give us an important competitive advantage in the preclinical sector |
| Statement |
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| Sales of small models were the principle headwind to fourth quarter growth as well as continued softness in the cell solutions business |
| And the DSA operating margin also contributed with a small year-over-year decline driven by lower sales volume in the discovery business |
| As we previously mentioned, the biologics testing business had a difficult year due to tighter client spending in its end markets |
| Discovery services had a challenging year and saw a meaningful revenue decline in the fourth quarter across all client segments |
| In addition to the lower revenue and operating margin, a higher tax rate, as well as the 53rd week in 2022 and the divestiture of the avian vaccine business in the fourth quarter of 2022 were earnings headwinds |
| We reported revenue of $1.01 billion in the fourth quarter of 2023, a 3.5% decline on an organic basis |
| Demand for small research models across all client segments slowed conservatively in the fourth quarter, particularly in North America and Europe |
| The current demand environment will likely limit unit volume growth this year in the research model business in North America and Europe |
| The DSA operating margin was 26% in the fourth quarter, the 30 basis point decrease from the fourth quarter of 2022 due to the revenue decline in the discovery services business |
| DSA revenue in the fourth quarter was $625.8 million, a decrease at 6% on an organic basis |
| The decline from the fourth quarter will be primarily driven by a lower operating margin due in part to seasonal business trends |
| For the full-year, the operating margin declined by 70 basis points to 20.3% |
| The operating margin decreased 130 basis points year-over-year to 19.1% in the fourth quarter, principally driven by higher and allocated corporate costs due in part to a meaningful increase in health related expenses |
| Our biologics testing solutions and microbial solutions businesses both reported modest revenue declines in the fourth quarter |
| Earnings per share were $2.46 in the fourth quarter a decrease of 17.4% from $2.98 in the fourth quarter of 2022 |
| RMS revenue in the fourth quarter was $195.8 million, a decrease of 0.4% on an organic basis |
| The quarterly decline reflected the difficult comparison to the 26.5% growth rate last year, as well as a meaningful decline in the discovery services revenue in the fourth quarter, safety assessment revenue also decreased by the lower rate |
| The Biologics Testing business is also impacted by seasonally lower sample volumes in the first quarter |
| In 2023, the operating margin declined by 70 basis points to 20.3% |
| Patrick, as you pointed out, there are a few factors that are putting pressure on the Q1 margin and then throughout the year that those factors are going to ameliorate and the margin will ramp |
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