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| Institution | Shares | Value | Change |
|---|---|---|---|
| BAKER BROS. ADVISORS LP | 42,896,690 | $915,415,365 | 0.00% |
| BlackRock, Inc. | 20,268,644 | $432,532,865 | 0.00% |
| VANGUARD GROUP INC | 15,179,371 | $323,927,778 | 0.00% |
| STATE STREET CORP | 7,255,476 | $154,831,858 | 0.00% |
| RTW INVESTMENTS, LP | 7,144,524 | $152,464,142 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,132,644 | $66,859,595 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | 2,798,134 | $59,711,574 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,484,156 | $53,011,889 | 0.00% |
| Palo Alto Investors LP | 2,466,684 | $52,639,037 | 0.00% |
| BRAIDWELL LP | 2,378,655 | $50,760,498 | 0.00% |
| MARSHALL WACE, LLP | 2,358,881 | $50,338,520 | 0.00% |
| GOLDMAN SACHS GROUP INC | 2,102,450 | $44,866,283 | 0.00% |
| FIRST TRUST ADVISORS LP | 1,943,152 | $41,466,863 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,648,864 | $35,186,758 | 0.00% |
| CITIGROUP INC | 1,574,070 | $33,590,654 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | 1,567,035 | $33,440,527 | 0.00% |
| D. E. Shaw & Co., Inc. | 1,561,161 | $33,315,176 | 0.00% |
| DEUTSCHE BANK AG\ | 1,522,200 | $32,483,748 | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | $32,010,000 | 0.00% |
| Point72 Asset Management, L.P. | 1,486,357 | $31,718,857 | 0.00% |
| Institution | Action | Shares |
|---|---|---|
| UBS Group AG | BUY | 664,846 |
| Brevan Howard Capital Management LP | BUY | 34,992 |
| Sunbelt Securities, Inc. | BUY | 53 |
| CenterBook Partners LP | BUY | 11,152 |
| Mirae Asset Global Investments Co., Ltd. | BUY | 6,522 |
| Bridgewater Associates, LP | BUY | 163,245 |
| Quantbot Technologies LP | BUY | 26,064 |
| FINANCIAL CONSULATE, INC | BUY | 10 |
| Scientech Research LLC | BUY | 37,558 |
| Y-Intercept (Hong Kong) Ltd | BUY | 111,273 |
| Invesco Ltd. | BUY | 740,575 |
| HRT FINANCIAL LP | BUY | 40,070 |
| iSAM Funds (UK) Ltd | BUY | 4,349 |
| AlphaQuest LLC | BUY | 32,251 |
| Vestcor Inc | BUY | 22,601 |
| Frazier Life Sciences Management, L.P. | BUY | 613,837 |
| Binnacle Investments Inc | BUY | 19 |
| DNB ASSET MANAGEMENT AS | BUY | 13,177 |
| SouthState Bank Corp | BUY | 45 |
| Quantinno Capital Management LP | BUY | 11,200 |
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